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. 2021 Feb 20;26(4):1133. doi: 10.3390/molecules26041133

Figure 1.

Figure 1

Electrophoresis agarose gel showing inhibitory effects of tacrine-coumarin compounds 1a2c on human topoisomerase I (hTOPI) activity. Supercoiled plasmid DNA (pBR322—negative control) was incubated for 30 min with 2 U of hTOPI in the absence (lines hTOPI + pBR322—positive control) and presence of varying concentrations of compounds 1a-2c (lines 1a2c).