Table 2.

Effect of tacrine-coumarin hybrid compounds 1a–2c on cell cycle distribution.

Compound	Concentration (× 10−6 M)	G1	S	G2
Control	0	53.77 ± 1.43	33.43 ± 0.71	12.81 ± 0.94
1a	25	57.03 ± 0.86	31.02 ± 0.65	11.94 ± 1.37
	50	57.88 ± 1.68	30.56 ± 0.72	11.56 ± 0.99
1b	25	59.08 ± 1.32	29.64 ± 0.22	11.29 ± 1.36
	50	71.13 ± 1.59 *	21.72 ± 1.22 *	7.15 ± 1.29 *
1c	25	79.97 ± 1.25 *	14.64 ± 1.56 *	5.39 ± 0.9 *
	50	91.86 ± 2.24 *	6.09 ± 1.98 *	2.05 ± 0.62*
1d	25	86.21 ± 1.67 *	10.73 ± 0.97 *	3.06 ± 0.85 *
	50	80.85 ± 2.30 *	12.54 ± 3.46 *	6.61 ± 1.84 *
2a	25	55.54 ± 1.43	33.00 ± 1.03	11.46 ± 1.41
	50	56.94 ±1.20	32.06 ± 0.22	11.01 ± 1.07
2b	25	58.18 ± 0.35	30.51 ± 1.20	11.30 ± 0.86
	50	56.69 ± 2.40	32.49 ± 1.56	10.83 ± 0.9
2c	25	57.03 ± 2.74	31.77 ± 1.73	11.20 ± 1.21
	50	57.68 ± 1.24	31.80 ± 0.6	10.51 ± 1.67

* Statistical significance: p < 0.05 for each experimental group compared to untreated control.