Table 2.
Statistical results for the panel of features compared between the tumor patterns. Low p-values (<0.05) indicate significant differences between the feature data corresponding to the different morphological patterns.
Feature | Compart-ment | Kruskal-Wallis Test | Mann–Whitney U Test | |||||
---|---|---|---|---|---|---|---|---|
PP vs. TP | PP vs. FP | PP vs. CP | TP vs. FP | TP vs. CP | FP vs. CP | |||
ALDH1 | C | <0.001 | <0.001 | NS | NS | <0.001 | <0.001 | NS |
αSMA | S | <0.001 | <0.001 | 0.01 | <0.001 | <0.001 | 0.02 | <0.001 |
CAV1 | C | <0.001 | NS | NS | <0.001 | NS | <0.001 | <0.001 |
CAV1 | S | <0.001 | <0.001 | 0.006 | <0.001 | NS | <0.001 | <0.001 |
CD133 | C | <0.001 | <0.001 | NS | <0.001 | <0.001 | NS | <0.001 |
CD44 | C | 0.004 | 0.003 | 0.007 | 0.001 | NS | NS | NS |
Col align | S | 0.001 | 0.001 | 0.011 | 0.001 | <0.001 | <0.001 | NS |
Col I | S | <0.001 | 0.033 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 |
Col I pattern | S | <0.001 | <0.001 | <0.001 | <0.001 | NS | <0.001 | <0.001 |
Col III | S | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 |
Col III pattern | S | <0.001 | <0.001 | <0.001 | <0.001 | NS | <0.001 | <0.001 |
Ep prox prox | S | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 |
FN | S | <0.001 | <0.001 | 0.02 | <0.001 | <0.001 | <0.001 | <0.001 |
FN pattern | S | <0.001 | <0.001 | <0.001 | 0.009 | <0.001 | <0.001 | <0.001 |
HA | S | <0.001 | <0.001 | 0.002 | <0.001 | <0.001 | NS | <0.001 |
ITGα2 | C | <0.001 | <0.001 | 0.001 | <0.001 | NS | NS | NS |
ITGα2 | S | <0.001 | 0.002 | NS | <0.001 | 0.022 | NS | 0.002 |
ITGα5 | S | <0.001 | <0.001 | NS | <0.001 | <0.001 | <0.001 | <0.001 |
ITGα5 pattern | S | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 |
ITGβ1 | C | <0.001 | <0.001 | <0.001 | <0.001 | NS | <0.001 | <0.001 |
ITGβ1 | S | <0.001 | <0.001 | NS | <0.001 | <0.001 | NS | <0.001 |
Ki67 | C | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 |
MMP14 | C | <0.001 | 0.001 | <0.001 | 0.037 | <0.001 | <0.001 | <0.001 |
MMP14 | S | <0.001 | <0.001 | <0.001 | NS | <0.001 | <0.001 | <0.001 |
Stromal cell density | S | <0.001 | <0.001 | 0.008 | <0.001 | <0.001 | <0.001 | <0.001 |
Total collagen | S | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | NS |
ALDH1, aldehyde dehydrogenase 1; αSMA, α-smooth muscle actin; C, Cancer; CAV1, caveolin-1; Col, collagen; Col align, collagen alignment; CP, chicken-wire pattern; Ep prox, epithelial proximity; FN, fibronectin; FP, fascicular pattern; HA, hyaluronan; ITG, integrin; MMP14, matrix metalloproteinase 14; NS, not significant (p ≥ 0.05); PP, periglandular pattern; S, stroma; TP, tendon-like pattern.