Table 4.
Comparison of progression of symptoms and lung disease in patients with RA-ILD according to radiological pattern (UIP or NSIP).
| Variable | UIP | NSIP | p Value |
|---|---|---|---|
| Duration of follow-up, mean (SD) | 46.8 (14.5) | 47.5 (14.9) | 0.808 |
| Pulmonary function testing | |||
| Last FVC, mean (SD) | 67.6 (22.0) | 78.6 (25.4) | 0.037 |
| Last FEV1<, mean (SD) | 72.1 (21.9) | 78.2 (20.7) | 0.225 |
| Last DLCO, mean (SD) | 66.9 (18.5) | 70.1 (16.7) | 0.235 |
| HRCT | |||
| Course | 0.002 | ||
| Progression, n (%) | 27 (38.0) | 9 (22.0) | |
| Stabilization, n (%) | 44 (62.0) | 26 (63.4) | |
| Improvement, n (%) | 0 (0.0) | 6 (14.6) | |
| Progression of lung disease (total) * | 0.032 | ||
| Improvement, n (%) | 2 (2.8) | 6 (14.6) | |
| Stabilization, n (%) | 38 (53.5) | 25 (61.0) | |
| Worsening, n (%) | 16 (22.5) | 7 (17.1) | |
| Death, n (%) | 15 (21.1) | 3 (7.3) | |
| Inflammatory activity | |||
| Last DAS28, mean (SD) | 3.3 (1.1) | 3.2 (1.4) | 0.428 |
| Last C-reactive protein, mean (SD) | 18.5 (16.9) | 8.6 (7.3) | 0.037 |
| Last ESR, mean (SD) | 26.1 (17.4) | 23.2 (18.2) | 0.823 |
| Last HAQ, mean (SD) | 1.5 (0.7) | 1.2 (0.7) | 0.341 |
RA: rheumatoid arthritis; ILD: interstitial lung disease; DMARD: disease-modifying antirheumatic drug; SD: standard deviation; FVC: forced vital capacity; FEV1: forced expiratory volume in the first second; DLCO: diffusing capacity of the lung for carbon monoxide; UIP: usual interstitial pneumonia; NSIP: nonspecific interstitial pneumonia; HRCT: high-resolution computed tomography; DAS28: 28-joint Disease Activity Score; ESR: erythrocyte sedimentation rate; HAQ: Health Assessment Questionnaire; * Progression of lung disease (total): taking into account HRCT and pulmonary function testing (FVC and DLCO).