Table 4.

IPTW-adjusted mean difference in pre– to post–PEx treatment ppFEV1, return to ≥90% of baseline ppFEV1, and time to next PEx requiring i.v. antibiotics, by number of i.v. and inhaled antipseudomonal antibiotics

Antibiotic Combination	Change in ppFEV1 Estimate [% (95% CI)]	P Value	Return to ≥90% of Baseline ppFEV1 [Odds Ratio (95% CI)]	P Value	Time to Next PEx [Hazard Ratio (95% CI)]	P Value
Two i.v. and one inhaled	−1.16 (−2.05 to −0.28)	0.01	0.92 (0.79 to 1.08)	0.30	1.04 (0.96 to 1.12)	0.31
One i.v. and one inhaled	−0.30 (−1.45 to 0.86)	0.61	0.98 (0.78 to 1.22)	0.84	1.11 (1.01 to 1.23)	0.04
One i.v. and no inhaled	−0.33 (−1.24 to 0.57)	0.47	0.89 (0.75 to 1.06)	0.20	1.08 (0.99 to 1.17)	0.072

Definition of abbreviations: CI = confidence interval; IPTW = inverse probability of treatment weighting; i.v. = intravenous; PEx = pulmonary exacerbation; ppFEV₁ = percent predicted forced expiratory volume in 1 second.

Antibiotic category reference (two i.v.; no inhaled).