TABLE V.

LAMA key questions and recommendations

Question	Intervention	Comparator	Recommendation	Certainty of evidence
5.1	LAMA as an add-on to ICS controller therapy*	LABA as an add-on to same-dose ICS controller therapy*	14: Conditional, against intervention	Moderate
		Montelukast as an add-on to same-dose ICS controller therapy*	No recommendation†
5.2	LAMA as an add-on to ICS controller therapy*	Same-dose ICS controller therapy* + placebo	15: Conditional, in favor of the intervention	Moderate
		Increased ICS dose	No recommendation†
5.3	LAMA as an add-on to ICS-LABA	Same-dose ICS-LABA as controller therapy*	16: Conditional, in favor of the intervention	Moderate
		Doubled ICS dose + LABA	No recommendation†

^*ICS controller therapy used daily.

^†Insufficient evidence.