Figure 9.

Caspase 3/7 activity. The ability of MMB + CFM-4.16 combinations to induce apoptosis was evaluated in MDA-MB-231 and MDA-MB-468 by Caspase-Glo 3/7 kit. At which, the cells were treated with MMB, CFM-4.16, free combo, NT-combo, and T-combo). The luminescence intensity is directly proportional to the amount of caspase activity present. The data are presented as a mean ± SEM (n = 3), the means were compared by analysis of variant, post hoced with Tukey, different letters indicate significant difference. Note: T combo (CD44-T-PNPs + MMB) and NT combo (NT-PNPs + MMB) and free combo (CFM-4.16 + MMB) where MMB means momelotinib.