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CD44 overexpression in TNBC- bearing mice model. The expression of CD44 in MDA-MB-231- induced TNBC in mice is considered the basis for the selection of HA as a targeting ligand for PNPs. Alexa Fluor 488 conjugated anti-CD44 antibody was used to demonstrate the homogenous distribution of CD44 receptors on the in vivo tumor. The images were taken by a confocal microscope with 10× and 63× magnification power.
