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View full-text article in PMC

. 2021 Feb 20;13(4):898. doi: 10.3390/cancers13040898

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Theranostic NT-PNPs/S0456 and CD44-T-PNPs/S0456 in TNBC-bearing mice model. Free S0456 (A), NT-PNPs/S0456 (B), and CD44-T-PNPs/S0456 (C) were injected via tail-vein into TNBC- bearing mice. The targeted theranostic PNPs showed highly selective tumor uptake, favorable tumor-selective bio-distribution, and payload sustained-release (C), Whereas non-targeted theranostic PNPs have minimal tumor uptake with non-specific organ bio-distribution (B). The free dye was rapidly eliminated with neglectable tumor accumulation (C). Whole-body fluorescence and X-ray merged images were acquired at 24 and 72 h post-injection.