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The capability of T combo to enhance the onset of apoptosis in TNBC- bearing mice by CD44. HA mediated endocytosis. T combo was able to drive the tumor to the late-stage apoptosis, which is based on generating multiple DNA double-strand breaks (DSBs) with accessible 3’-hydroxyl (3’-OH) groups that were detected by TUNEL. Elevated apoptosis is indicated by brownish discoloration or dark brown spots. Note: T combo (CD44-T-PNPs + MMB) where MMB means momelotinib. Magnification is 40×.
