Table 2.

Clinical Study: Respiratory Mechanics, Oxygenation, Collapse and Overdistension, and Regional Crs

	LungARDSnet [Mean ± SD or Median (IQR)]	LungRECRUITED [Mean ± SD or Median (IQR)]	Difference (CI)*	P Value
Vt, ml/IBW	6.3 ± 0.9	6.3 ± 0.8	0.1 (-0.1 to 0.2)	0.23
RR, bpm	25.1 ± 6.0	25.2 ± 6.0	0.1 (-0.1 to 0.3)	0.33
PEEP, cm H2O	13 ± 1	21 ± 3	8 (7 to 10)	<0.01
PesEXP, cm H2O	17.1 ± 4.5	19.5 ± 5.1	2.4 (1.3 to 3.4)	<0.01
PlE, cm H2O	−4.3 ± 4.2	1.4 ± 3.6	5.7 (4.3 to 7.2)	<0.01
Plateau pressure, cm H2O	25.6 ± 3.9	30.4 ± 4.5	4.8 (3.4 to 6.3)	<0.05
DP, cm H2O	13 ± 4	9 ± 2	−4 (-6 to −2)	<0.01
Crs, ml/cm H2O	33 (24 to 41)	41 (31 to 51)	11 (5 to 14)	<0.01
PaO2/FiO2	179 ± 108	308 ± 90	129 (64 to 194)	<0.01
Collapse determined by EIT, % (n = 18)	38 ± 11	7 ± 6	−31 (-36 to −25)	<0.01
Overdistension determined by EIT, % (n = 18)	7 ± 7	9 ± 6	2 (-2 to 6)	0.33
Regional Crs, ΔZ/cm H2O (n = 10)
ROI-1	8.9 ± 4.7	7.3 ± 2.8	−1.7 (-3.6 to 0.2)	0.07
ROI-2	19.1 ± 8.1	25.5 ± 8.4	6.3 (4.3 to 8.4)	<0.01
ROI-3	5.1 ± 2.8	10 ± 3.2	4.9 (2.9 to 6.9)	<0.01

Definition of abbreviations: bpm = beats per minute; CI = confidence interval; Crs = respiratory system compliance; ΔZ = delta impedance; DP = driving pressure; EIT = electrical impedance tomography; IBW = ideal body weight; IQR = interquartile range; Lung_ARDSnet = mechanical ventilation guided by the Acute Respiratory Distress Syndrome Network; Lung_RECRUITED = a sequence of procedures (lung recruitment maneuver → decremental PEEP trial → second lung recruitment maneuver → optimal PEEP) to recruit lung atelectasis; PEEP = positive end-expiratory pressure; Pes_EXP = end-expiratory pleural pressure; Pl_E = end-expiratory transpulmonary pressure; ROI = region of interest; RR = respiratory rate.

N = 19 patients.

^*A median of differences and 98.08% CI are shown for Crs; mean differences and 95% CIs are shown for other categories.