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. 2021 Feb 20;22(4):2123. doi: 10.3390/ijms22042123

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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After muscle injury, the expression levels of collagen genes were upregulated, and collagen deposition in aged muscle was diminished. (A) Protein level of col1a1 expression in young and old muscle after damage. ND, nondamaged muscle which was from contralateral leg of the damaged muscle as a control. D, fourteen days after BaCl₂ muscle injury. (B) Quantitative results of collagen 1a1 (bands 1, 2, and 3 in total from Figure 3A) expression in young and aged muscle. There were 3 mice in each group. (C) Quantitative results of pro-collagen (band 1 in Figure 3A) expression in young and aged muscle. There were 3 mice in each group. (D) Quantitative RT-qPCR mRNA expression of collagen genes in young and aged skeletal muscle after damage. Five mice in each group. (E) Quantitative data of RT-qPCR mRNA expression of myogenesis-related genes in young and aged skeletal muscle after damage. The results are presented as the mean ± SD. * p < 0.05; ** p < 0.005; *** p < 0.001.