Figure 4.

Innate receptor activation pattern for rhinoviruses (from Table 2) based on the model in Figure 2A,B and data summarized in Table 2. Only TLR3, TLR7 and possibly RIG1 are activated, while the other receptors are not (faded), resulting in a single synergistic interaction and no known antagonistic ones. Cytokine release should, according to this model, be minimal following rhinovirus infection, perhaps explaining its mild symptoms. Note the differences in this activation pattern compared with Figure 3A–C and Figure 5 and Figure 6 below). See Table 1 and Table 2 for abbreviations.