Figure 3.

OPLS loadings column plot of the association of total and HMW adiponectin with clinical markers of disease activity. OPLS models depicting the association between total (A) and HMW (B) adiponectin with clinical markers of disease activity. X-variables represented by a bar pointing in the same direction as the y-variable (adiponectin) were associated with higher total or HMW adiponectin, whereas x-variables represented by a bar pointing in the opposite direction were related to lower total or HMW adiponectin. Only variables associated with plasma total/HMW adiponectin in the OPLS analysis were tested for significance with linear regression analyses. Abbreviations: CDAI, clinical disease activity index; CRP, C-reactive protein; DAS28, disease activity score in 28 joints; ESR, erythrocyte sedimentation rate; HMW, high molecular weight; OPLS, orthogonal projection to latent structures; SJC28, swollen joint counts of 28; TJC28, tender joint counts of 28.