Fig 5. Dose fractionation of AmBisome.

Total doses of 2.5 mg/kg (A) and 1.25 mg/kg (B) were administered either as one dose (x1), one-half of the dose every 24 hours (x2) or one-fourth of the dose every 12 hours (x4). Treatment outcome is expressed as percentage inhibition, where columns represent group means (n = 6) and error bars standard deviations. Mean LDU +/- standard deviation in an untreated control group was 655 +/- 76. Data for the 2.5 mg/kg dose is representative of 2 separate experiments.