Table 3. Protein binding of amphotericin B and miltefosine in plasma and tissue.
% bound (mean +/- SD, n = 3) | |||||
Dosing | Hours post dose | Plasma | Liver | Spleen | |
AmBisome | 40 mg/kg x1 | 24 | 99.60 +/- 0.41 | 99.98 +/- 0.00 | 99.96 +/- 0.02 |
Miltefosine | 30 mg/kg x1 | 1 | 99.92 +/- 0.06 | 99.97 +/- 0.00 | 99.93 +/- 0.07 |
Miltefosine | 30 mg/kg x5 | 1 | 99.98 +/- 0.00 | 99.99 +/- 0.00 | 99.99 +/- 0.00 |