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. 2021 Feb 18;15(2):e0008770. doi: 10.1371/journal.pntd.0008770

Fig 4. In vitro validation of S. mansoni oligonucleotides containing PQS by circular dichroism.

Fig 4

Oligonucleotides containing predicted PQS within Smps were annealed in the presence of K+ before cooling and recording spectra by circular dichroism. A) smp_139180, smp_145140 and smp_163240 compared to c-myc control, indicating a parallel G4 conformation. B) smp_319480 and smp_127680 in comparison to smTelo control, with spectra indicative of an anti-parallel hybrid quadruplex. C) smp_196840 with both controls, indicating a spectra readout that does not correlate with either parallel or hybrid quadruplex formation.