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. 2021 Feb 21;22(4):2136. doi: 10.3390/ijms22042136

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Methylation-profiling array: Volcano plot for differential methylation in 10 pregnancies (cases 1–10). (A) Volcano plot for differential methylation in CpG sites, quantified using methylation score differences between cord blood and placenta (x-axis) and the p-value of each region (y-axis). Points identify differentially methylated sites that are hypermethylated in placenta (left portion of the plots) or hypermethylated in cord blood (right portion of the plots). Color scale is based on a combined ranking. (B) Volcano plots for differential methylation in tiling, genes, promoters, and CpG islands.