Figure 1.
Schematic representation of lipopolysaccharide (LPS) biosynthesis, leading to the production of the inner part of the LPS (lipid A), as depicted in the complex pathway identified using the Kyoto Encyclopedia of Genes and Genomes (KEGG) database. The pathway corresponds to endotoxin production and involves nine essential enzymes (indicated in red), including rate-limiting enzymes. The Enzyme Commission numbers and products are in green and blue, respectively. Lipid X, 2,3-diacyl-GlcN-1-phosphate; Lipid IVA, lipid A disaccharide bisphosphate; KDO2, 2-keto-3-deoxy-D-mannooctanoic acid.