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. Author manuscript; available in PMC: 2021 Mar 2.
Published in final edited form as: J Pineal Res. 2019 Oct 7;67(4):e12610. doi: 10.1111/jpi.12610

FIGURE 2.

FIGURE 2

Melatonin decreases melanin content in MNT-1 melanoma cells. Based on assessment carried out by electron paramagnetic resonance (EPR) spectroscopy, here the spectra of (A) synthetic DOPA-melanin used as standard for melanin determination; (B) synthetic cysteine-L-DOPA melanin indicating the characteristic of EPR signal of pheomelanin, and cells after 72 h incubation with melatonin in dose-dependent manner are depicted (C). Bar graph displays mean values + SD (n = 3) of pg of melanin per cell in melatonin-treated cells (D). Statistically significant differences versus control were indicated as *P < .05, **P < .01, ***P < .001