Table 4.
List of individual miRNAs associated with OFCs in human population or patient-derived tissue studies. CL/P, cleft lip with or without cleft palate; CLO, cleft lip only; CPO, cleft palate only; OFC, orofacial cleft.
| miRNA | Target genes | Populations | Associated OFCs | References |
|---|---|---|---|---|
| miR-140 | - | Han Chinese individuals OFC: n = 557 NSD: n = 306 |
CPO | (L. Li et al., 2010) |
| PDGFRA | Han Chinese Individuals CPO: n = 169 NSD: n = 306 |
CPO | (L. Li et al., 2011) | |
| PDGFRA | Thai individuals CPO: n = 102 NSD: n = 500 |
CPO | (Rattanasopha et al., 2012) | |
| miR-3649 | MSX1 | Individuals from China OFC: n = 602 CLO: n = 238 CPO: n = 56 CL/P: n = 305 NSD: n = 605 |
CL/P | (L. Ma et al., 2014) |
| miR-145 | FGF5 | Individuals from China OFC: n = 602 CLO: n = 232 CPO: n = 49 CL/P: n= 289 NSD: n = 605 |
CLO, CPO | (D. Li et al., 2016) |
| miR-187 | FGF9 | OFC | ||
| miR-469 | FGF2 | CLO, CL/P | ||
| miR-423-3p | FOXE1 | Individuals from China OFC: n = 602 NSD: n = 605 No n values given for subtypes |
CLO | (Yin et al., 2016) |
| miR-24-3p | - | Individuals from China CL/P: 4 NSD: 4 |
CL/P | (S. Wang et al., 2017) |
| miR-1260b | - | |||
| miR-205-5p | - | |||
| miR-18a-5p | - | Dutch children 29 months old or younger CL/P: n = 8 CPO: n = 5 NSD: n = 10 |
CPO | (Schoen et al., 2018) |
| miR-181a | - | |||
| miR-29c-5p | - | |||
| miR-3182 | - | |||
| miR-451a | - | |||
| miR-549a | - | |||
| miR-92a-3p | ||||
| miR-92b-5p | - | |||
| miR-93-5p | - | |||
| miR-505-3p | - | CL/P | ||
| miR-146a | TRAF6 | Individuals from China OFC: n = 1406 CL/P: n = 1197 CPO: n = 206 NSD: n = 1578 |
CL/P CPO |
(Pan et al., 2018) |