Fig. 1.

Host proteome changes in cervicovaginal mucus over time in adolescent girls using dapivirine and placebo vaginal rings.

Volcano plots displaying human cervicovaginal proteins differentially abundant between visits in both the dapivirine (a) and placebo (b) arms using one-way repeated measures ANOVA with Tukey's correction for multiple comparisons. (c) Hierarchical clustering of differentially abundant (P adjusted <0.05) proteins in dapivirine arm and placebo (d) arm. Overabundant proteins are represented in red and those that are underabundant are represented in blue. Baseline, follow-up visit 1, and follow-up visit 2 are shown.