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. 2021 Mar 1;10:e65339. doi: 10.7554/eLife.65339

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© 2021, Chen et al

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Figure 7. — (A) The observed selectivity of compound 2 appears to arise from interactions made with amino acids of the Zn-binding domain ‘Helical Hairpin’ that are poorly conserved (or absent) from the other RecQ-family helicases. For each multiple amino acid sequence alignment shown, highly conserved amino acids are coloured in red. Those conserved in at least two RecQ family members (low consensus) are coloured blue. Amino acids residues of human BLM involved in interactions with 2 are additionally highlighted. Please see associated key for additional information. (B) A speculative model for how the HRDC domain may contribute to the unwinding of a DNA duplex or a Holliday junction (inset) via transient interactions with the passive or ‘inactive’ strand. See associated key for additional details.