Table 4. Definition of modules in the glycolysis network shown in Figure 5—figure supplement 1.

Enzyme abbreviations are listed in Table 6. Metabolite abbreviations are listed in Table 5.

Model	Internal metabolites	Concentrations of I/O metabolites	Reactions	Output flux
UGPP	6 pg, dhap, e4p, f6p, fdp, rib5p, ribu5p, sed7p, xyl5p	[g6p]=3.82 mM, [gap]=0.44 mM	ALDO, G6PDH, PFK, PGDH, PGI, Ru5P, R5PI, TA, TIS, TKa, TKb	$J_{\mathrm{ALDO}}+J_{\mathrm{TIS}}+J_{\mathrm{TKb}}+J_{\mathrm{TKa}}-J_{\mathrm{TA}}$
LG	2 pg, 3 pg, pgp	[gap]=0.44 mM, [pep]=0.08 mM	ENO, GAPDH, PGK, PGM	$J_{\mathrm{ENO}}$
GPP	all in UGPP and in LG, gap	[g6p]=3.82 mM, [pep]=0.08 mM	all in UGPP and in LG	$J_{\mathrm{ENO}}$
FULL	all in GPP, g6p, pep	[Ext glu]=2 µM, [pyr]=10 µM	all in GPP, PTS, PK, PEPCxyl	$J_{\mathrm{PK}}+J_{\mathrm{PTS}}$