Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Mar 1;10:e63333. doi: 10.7554/eLife.63333

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2021, Zhang et al

This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.

PMC Copyright notice

Figure 4. — (A) UMAP showing clustering of the neuronal subtypes of the hypothalamus-POA based on single-cell transcriptomics, overlayed with identity named for top expressed cluster defining marker gene. (B) Dot plot showing expression of neuronal cluster defining markers, Esr1, Esr2, Gper1, and Pgr. (C) Volcano plots of tamoxifen-induced or repressed differentially expressed genes (DEGs) overlayed with gene sets (GS) involved in neuropeptide signaling, oxidative phosphorylation, or glycolysis. Analyses done from wild-type female mice injected daily with oil (n = 3) or tamoxifen (n = 5) over 28 days. NES: Normalized enrichment score, GSEA adj. p: Benjamini-Hochberg adjusted p-value, DEG adj. p: Bonferroni adjusted p-value.

Figure 4—figure supplement 1. — (A) UMAP showing clustering of the neuronal subtypes of the hypothalamus-POA based on single-cell transcriptomics, overlayed with identity named for top expressed cluster defining marker gene. (B) Dot plot showing expression of neuronal cluster defining markers, Esr1, Esr2, Gper1, and Pgr. (C) Volcano plots of tamoxifen-induced or repressed differentially expressed genes (DEGs) overlayed with gene sets (GS) involved in neuropeptide signaling, oxidative phosphorylation, or glycolysis. Analyses done from wild-type female mice injected daily with oil (n = 3) or tamoxifen (n = 5) over 28 days. NES: Normalized enrichment score, GSEA adj. p: Benjamini-Hochberg adjusted p-value, DEG adj. p: Bonferroni adjusted p-value.