TABLE 5.

Marginal effects of 24 verified supervariants on discovery, validation, and combined datasets

Supervariant	Discovery dataset		Validation dataset		Combined dataset
Recessive	Odds ratio (OR)	p	OR	p	OR	p
Chr1_122	0.853	2.43 × 10−5	0.89	8.74 × 10−3	0.875	8.13 × 10−7
Chr2_218	1.189	2.39 × 10−9	1.31	1.55 × 10−11	1.25	6.37 × 10−19
Chr3_28	0.832	1.10 × 10−5	0.864	2.56 × 10−3	0.85	1.07 × 10−7
Chr6_152	1.186	1.70 × 10−5	1.3	3.84 × 10−6	1.25	1.24 × 10−9
Chr9_84	1.378	2.55 × 10−5	1.32	2.80 × 10−3	1.35	2.55 × 10−7
Chr10_124	1.391	6.55 × 10−19	1.37	4.54 × 10−12	1.388	8.65 × 10−30
Chr16_53	1.529	4.69 × 10−13	1.47	1.66 × 10−7	1.5	4.60 × 10−19
Dominant	OR	p	OR	p	OR	p
chr2_203	1.136	1.24 × 10−5	1.117	2.11 × 10−3	1.128	9.80 × 10−8
chr2_214	1.159	9.91 × 10−6	1.118	6.20 × 10−3	1.142	2.52 × 10−7
chr3_28	0.842	1.14 × 10−8	0.907	9.26 × 10−3	0.867	1.26 × 10−9
chr5_13	0.618	6.49 × 10−6	0.712	8.46 × 10−3	0.654	2.27 × 10−7
chr5_45	1.171	2.32 × 10−7	1.182	8.33 × 10−6	1.176	8.88 × 10−12
chr5_56	1.233	2.89 × 10−12	1.236	1.05 × 10−8	1.235	1.75 × 10−19
chr5_57	1.25	5.21 × 10−13	1.250	4.23 × 10−9	1.25	1.31 × 10−20
chr5_174	1.201	2.55 × 10−7	1.130	4.75 × 10−3	1.172	7.32 × 10−9
chr7_156	1.378	1.40 × 10−5	1.279	5.24 × 10−3	1.337	2.88 × 10−7
chr8_129	1.162	1.59 × 10−6	1.152	2.22 × 10−4	1.158	1.41 × 10−9
chr9_111	0.857	2.25 × 10−7	0.895	2.46 × 10−3	0.872	3.03 × 10−9
chr10_65	0.83	4.86 × 10−8	0.879	1.96 × 10−3	0.849	6.42 × 10−10
chr10_124	1.418	1.69 × 10−27	1.387	9.95 × 10−17	1.406	1.54 × 10−42
chr11_70	1.222	5.57 × 10−11	1.265	3.95 × 10−10	1.239	1.68 × 10−19
chr12_97	0.879	1.12 × 10−5	0.886	8.56 × 10−4	0.882	3.66 × 10−8
chr16_53	1.323	9.50 × 10−22	1.289	1.93 × 10−12	1.309	1.57 × 10−32
chr22_29	2.536	2.07 × 10−8	3.700	2.87 × 10−9	2.897	7.41 × 10−16