TABLE 6.
Recessive | Chr | SNP name | Position | Minor allele | Major allele | MAF | OR | p |
---|---|---|---|---|---|---|---|---|
Chr1_122 | 1 | rs12026807 | 121274278 | G | A | 0.48 | 0.875 | 8.13 × 10−7 |
Chr2_218 | 2 | rs6721996 | 217909463 | G | A | 0.491 | 1.247 | 5.67 × 10−18 |
rs4442975 | 217920769 | G | T | 0.491 | 1.253 | 1.88 × 10−18 | ||
Chr3_28 | 3 | rs73055736 | 27392625 | A | T | 0.416 | 0.855 | 4.75 × 10−7 |
rs73055746 | 27399466 | C | T | 0.417 | 0.857 | 6.57 × 10−7 | ||
rs12637322 | 27389740 | C | T | 0.416 | 0.854 | 4.52 × 10−7 | ||
rs2370959 | 27397148 | A | G | 0.414 | 0.852 | 3.28 × 10−7 | ||
rs55676236 | 27391598 | C | A | 0.419 | 0.859 | 9.24 × 10−7 | ||
rs112238765 | 27388820 | A | C | 0.416 | 0.855 | 5.29 × 10−7 | ||
rs73055753 | 27403304 | C | T | 0.416 | 0.854 | 4.17 × 10−7 | ||
Chr6_152 | 6 | rs6913578 | 151949806 | C | A | 0.325 | 1.222 | 1.14 × 10−8 |
rs7740686 | 151948173 | T | A | 0.333 | 1.216 | 1.47 × 10−8 | ||
rs6557160 | 151949582 | C | A | 0.333 | 1.214 | 1.88 × 10−8 | ||
rs58164038 | 151956201 | G | A | 0.329 | 1.237 | 1.46 × 10−9 | ||
rs3757322 | 151942194 | G | T | 0.336 | 1.205 | 5.39 × 10−8 | ||
Chr9_84 | 9 | rs12551463 | 83471165 | G | T | 0.162 | 1.35 | 2.55 × 10−7 |
Chr10_124 | 10 | rs2981584 | 123350216 | A | C | 0.4 | 1.388 | 8.65 × 10−30 |
Chr16_53 | 16 | rs112149573 | 52581245 | T | G | 0.241 | 1.453 | 1.65 × 10−17 |
rs3095606 | 52584173 | G | A | 0.262 | 1.443 | 2.13 × 10−19 | ||
rs1362548 | 52563951 | C | G | 0.26 | 1.427 | 4.71 × 10−18 | ||
rs3112578 | 52585440 | C | T | 0.245 | 1.433 | 9.50 × 10−17 | ||
rs1345388 | 52556293 | C | T | 0.259 | 1.433 | 2.74 × 10−18 | ||
rs3095607 | 52584295 | G | T | 0.262 | 1.444 | 1.80 × 10−19 | ||
rs17271951 | 52538040 | C | T | 0.254 | 1.45 | 9.33 × 10−19 | ||
rs4784226 | 52583143 | T | C | 0.242 | 1.442 | 6.27 × 10−17 | ||
rs4784227 | 52599188 | T | C | 0.244 | 1.455 | 5.63 × 10−18 | ||
rs3803661 | 52586477 | A | G | 0.262 | 1.44 | 2.97 × 10−19 | ||
rs12930156 | 52581424 | T | C | 0.262 | 1.441 | 3.28 × 10−19 | ||
rs3803662 | 52586341 | A | G | 0.262 | 1.44 | 3.27 × 10−19 | ||
rs7500427 | 52545277 | A | G | 0.258 | 1.443 | 6.64 × 10−19 | ||
rs12600239 | 52538900 | T | C | 0.257 | 1.444 | 9.56 × 10−19 | ||
rs35668161 | 52538825 | A | C | 0.254 | 1.452 | 5.97 × 10−19 | ||
rs9936081 | 52549646 | A | G | 0.258 | 1.437 | 1.46 × 10−18 | ||
rs8045285 | 52579986 | G | A | 0.246 | 1.452 | 5.26 × 10−18 | ||
Dominant | Chr | SNP name | Position | Minor allele | Major allele | MAF | OR | p |
Chr2_203 | 2 | rs3769823 | 202122995 | A | G | 0.28 | 1.128 | 9.80 × 10−8 |
Chr2_214 | 2 | rs7580977 | 213473493 | T | G | 0.21 | 1.102 | 3.12 × 10−5 |
rs190740846 | 213176997 | C | T | 0.009 | 1.201 | 2.55 × 10−2 | ||
rs61521361 | 213496258 | A | T | 0.344 | 1.095 | 9.06 × 10−5 | ||
rs2054613 | 213484354 | G | C | 0.354 | 1.097 | 7.25 × 10−5 | ||
rs10174150 | 213487269 | C | T | 0.354 | 1.095 | 8.93 × 10−5 | ||
rs11679805 | 213494947 | T | A | 0.344 | 1.095 | 8.37 × 10−5 | ||
rs5838347 | 213547305 | AT | A | 0.406 | 1.132 | 2.86 × 10−7 | ||
rs6736536 | 213429063 | T | C | 0.341 | 1.086 | 3.39 × 10−4 | ||
rs13410624 | 213499043 | G | A | 0.344 | 1.096 | 7.43 × 10−5 | ||
rs2054615 | 213484752 | T | C | 0.354 | 1.097 | 7.08 × 10−5 | ||
rs7601545 | 213483894 | A | G | 0.354 | 1.097 | 7.08 × 10−5 | ||
rs66535530 | 213499028 | T | C | 0.299 | 1.099 | 3.44 × 10−5 | ||
rs6435714 | 213442905 | T | G | 0.342 | 1.085 | 3.56 × 10−4 | ||
rs67447343 | 213490466 | C | G | 0.347 | 1.093 | 1.31 × 10−4 | ||
rs6749009 | 213482684 | A | G | 0.354 | 1.097 | 7.26 × 10−5 | ||
rs67535717 | 213492898 | A | G | 0.354 | 1.095 | 1.00 × 10−4 | ||
rs62186335 | 213475881 | T | C | 0.21 | 1.102 | 3.30 × 10−5 | ||
rs6712252 | 213488021 | T | C | 0.354 | 1.096 | 8.24 × 10−5 | ||
rs2068404 | 213484997 | C | T | 0.354 | 1.097 | 7.08 × 10−5 | ||
rs931216 | 213493825 | T | C | 0.3 | 1.098 | 3.90 × 10−5 | ||
rs7606156 | 213485596 | A | G | 0.356 | 1.095 | 8.88 × 10−5 | ||
rs13020448 | 213438055 | T | C | 0.342 | 1.084 | 4.33 × 10−4 | ||
rs931218 | 213496624 | A | C | 0.299 | 1.099 | 3.70 × 10−5 | ||
rs6708862 | 213487661 | T | C | 0.354 | 1.096 | 8.30 × 10−5 | ||
rs6435717 | 213535690 | A | G | 0.384 | 1.121 | 1.40 × 10−6 | ||
rs10221625 | 213541714 | T | C | 0.362 | 1.123 | 6.87 × 10−7 | ||
rs7606703 | 213473115 | C | A | 0.21 | 1.102 | 2.99 × 10−5 | ||
rs4673675 | 213539145 | C | T | 0.363 | 1.122 | 8.61 × 10−7 | ||
rs72935050 | 213609001 | A | T | 0.073 | 1.06 | 7.35 × 10−2 | ||
rs17330768 | 213494330 | G | T | 0.3 | 1.099 | 3.75 × 10−5 | ||
rs11676391 | 213485772 | C | T | 0.354 | 1.097 | 7.08 × 10−5 | ||
rs6736377 | 213428760 | A | G | 0.341 | 1.086 | 3.45 × 10−4 | ||
rs140149813 | 213243507 | G | C | 0.004 | 1.259 | 6.02 × 10−2 | ||
rs6749157 | 213482781 | C | G | 0.354 | 1.097 | 7.30 × 10−5 | ||
rs6711917 | 213487687 | T | C | 0.356 | 1.095 | 1.00 × 10−4 | ||
rs2128324 | 213490883 | A | G | 0.356 | 1.094 | 1.13 × 10−4 | ||
rs4673676 | 213539645 | T | C | 0.363 | 1.118 | 1.65 × 10−6 | ||
2:213537990_TACCC_T | 213537990 | T | TACCC | 0.365 | 1.119 | 1.75 × 10−6 | ||
rs142052382 | 213493752 | GA | G | 0.334 | 1.091 | 2.16 × 10−4 | ||
rs34741122 | 213498134 | G | A | 0.299 | 1.099 | 3.53 × 10−5 | ||
rs10177496 | 213436989 | A | G | 0.221 | 1.086 | 3.30 × 10−4 | ||
rs57917865 | 213495985 | T | G | 0.347 | 1.092 | 1.39 × 10−4 | ||
rs10221626 | 213541719 | A | G | 0.362 | 1.123 | 6.87 × 10−7 | ||
rs199875963 | 213536531 | G | GT | 0.389 | 1.116 | 4.06 × 10−6 | ||
rs4673669 | 213477128 | A | C | 0.355 | 1.094 | 1.16 × 10−4 | ||
rs13394068 | 213533178 | C | T | 0.358 | 1.106 | 1.56 × 10−5 | ||
Chr3_28 | 3 | rs12637322 | 27389740 | C | T | 0.416 | 0.862 | 3.11 × 10−10 |
rs11714071 | 27377648 | G | A | 0.415 | 0.863 | 5.21 × 10−10 | ||
Chr5_13 | 5 | rs560776922 | 12563406 | G | A | 0.006 | 0.655 | 7.28 × 10−4 |
rs560646329 | 12573113 | C | T | 0.006 | 0.687 | 2.13 × 10−3 | ||
rs141667948 | 12970825 | C | T | 0.007 | 0.637 | 4.51 × 10−5 | ||
Chr5_45 | 5 | rs10941679 | 44706498 | G | A | 0.255 | 1.185 | 9.68 × 10−14 |
rs10043344 | 44926518 | A | T | 0.39 | 1.167 | 1.91 × 10−10 | ||
Chr5_56 | 5 | rs79299334 | 55991699 | A | G | 0.075 | 1.21 | 7.71 × 10−10 |
rs16886128 | 55998085 | C | A | 0.103 | 1.165 | 3.23 × 10−8 | ||
rs74773564 | 55995869 | T | C | 0.075 | 1.211 | 5.79 × 10−10 | ||
rs77367410 | 55992290 | G | A | 0.075 | 1.212 | 4.91 × 10−10 | ||
rs16886113 | 55995035 | G | T | 0.079 | 1.216 | 1.19 × 10−10 | ||
rs74626386 | 55990052 | T | G | 0.089 | 1.21 | 5.83 × 10−11 | ||
Chr5_57 | 5 | rs61489170 | 56021469 | GA | G | 0.165 | 1.25 | 1.44 × 10−20 |
rs7714232 | 56011357 | T | A | 0.165 | 1.254 | 4.45 × 10−21 | ||
rs12653202 | 56016918 | C | A | 0.162 | 1.254 | 5.96 × 10−21 | ||
rs66893416 | 56051596 | A | G | 0.164 | 1.245 | 8.40 × 10−20 | ||
Chr5_174 | 5 | rs187944270 | 173955315 | A | G | 0.01 | 1.303 | 4.21 × 10−4 |
rs2909714 | 173814304 | T | C | 0.031 | 1.145 | 3.16 × 10−3 | ||
5:173903211_AT_A | 173903211 | A | AT | 0.005 | 0.898 | 3.71 × 10−1 | ||
rs555707527 | 173219789 | G | A | 0.003 | 1.424 | 9.70 × 10−3 | ||
rs962985 | 173767987 | C | A | 0.233 | 1.098 | 5.70 × 10−5 | ||
rs141509709 | 173926457 | T | C | 0.018 | 1.158 | 1.24 × 10−2 | ||
rs2913479 | 173779289 | C | T | 0.23 | 1.09 | 1.88 × 10−4 | ||
rs2913491 | 173810101 | A | T | 0.401 | 1.097 | 1.51 × 10−4 | ||
Chr7_156 | 7 | rs9718441 | 155094172 | T | C | 0.269 | 1.096 | 5.35 × 10−5 |
rs56181358 | 155867553 | A | G | 0.09 | 1.072 | 1.83 × 10−2 | ||
rs73174921 | 155844449 | A | G | 0.103 | 1.075 | 1.00 × 10−2 | ||
rs10245853 | 155097216 | G | A | 0.273 | 1.099 | 2.98 × 10−5 | ||
7:155202635_CTG_C | 155202635 | C | CTG | 0.253 | 1.022 | 3.50 × 10−1 | ||
rs10264491 | 155259716 | G | C | 0.346 | 1.01 | 6.65 × 10−1 | ||
rs141589981 | 155119687 | C | T | 0.008 | 1.204 | 3.16 × 10−2 | ||
rs143721983 | 155248281 | T | C | 0.01 | 0.819 | 2.38 × 10−2 | ||
rs28637616 | 155845220 | T | C | 0.102 | 1.073 | 1.24 × 10−2 | ||
rs6459701 | 155296003 | G | A | 0.108 | 1.06 | 3.89 × 10−2 | ||
rs73174937 | 155863201 | G | A | 0.09 | 1.081 | 8.54 × 10−3 | ||
rs28705370 | 155843988 | A | G | 0.104 | 1.074 | 1.06 × 10−2 | ||
rs6605564 | 155149763 | A | G | 0.262 | 1.087 | 2.50 × 10−4 | ||
rs12534832 | 155242699 | C | A | 0.388 | 1.051 | 3.56 × 10−2 | ||
rs73174920 | 155843148 | T | C | 0.103 | 1.075 | 1.06 × 10−2 | ||
Chr8_129 | 8 | rs12550713 | 128370949 | G | C | 0.405 | 1.152 | 4.37 × 10−9 |
rs10110330 | 128370755 | A | G | 0.405 | 1.153 | 3.32 × 10−9 | ||
rs594868 | 128344602 | A | G | 0.397 | 1.147 | 1.17 × 10−8 | ||
Chr9_111 | 9 | rs659713 | 110893949 | T | G | 0.376 | 0.875 | 9.04 × 10−9 |
rs522463 | 110886254 | G | T | 0.381 | 0.878 | 1.95 × 10−8 | ||
rs519679 | 110885947 | C | G | 0.381 | 0.878 | 1.73 × 10−8 | ||
9:110893720_GTATT_G | 110893720 | GTATT | G | 0.373 | 0.871 | 3.28 × 10−9 | ||
rs497006 | 110885781 | C | T | 0.381 | 0.878 | 1.67 × 10−8 | ||
rs628931 | 110893030 | A | G | 0.376 | 0.877 | 1.33 × 10−8 | ||
rs631475 | 110885650 | C | A | 0.382 | 0.876 | 1.09 × 10−8 | ||
rs676256 | 110895353 | C | T | 0.379 | 0.874 | 6.27 × 10−9 | ||
rs520613 | 110886052 | C | T | 0.381 | 0.878 | 1.89 × 10−8 | ||
rs648354 | 110887106 | G | A | 0.38 | 0.879 | 2.46 × 10−8 | ||
rs525142 | 110886534 | G | A | 0.381 | 0.878 | 1.72 × 10−8 | ||
rs662694 | 110887996 | C | G | 0.38 | 0.879 | 2.30 × 10−8 | ||
rs7862747 | 110892899 | C | A | 0.378 | 0.875 | 9.66 × 10−9 | ||
rs630965 | 110885479 | C | T | 0.382 | 0.876 | 1.14 × 10−8 | ||
rs3119744 | 110895863 | A | C | 0.377 | 0.876 | 9.71 × 10−9 | ||
rs527071 | 110886745 | C | A | 0.38 | 0.879 | 2.59 × 10−8 | ||
rs857609 | 110888677 | G | C | 0.38 | 0.88 | 2.92 × 10−8 | ||
Chr10_65 | 10 | rs34511355 | 64276964 | C | A | 0.142 | 0.849 | 6.42 × 10−10 |
Chr10_124 | 10 | rs2981584 | 123350216 | A | C | 0.4 | 1.391 | 3.14 × 10−41 |
rs2981575 | 123346116 | G | A | 0.4 | 1.394 | 7.12 × 10−42 | ||
rs1219651 | 123344501 | A | G | 0.398 | 1.392 | 1.50 × 10−41 | ||
rs2912774 | 123348662 | T | G | 0.4 | 1.395 | 8.39 × 10−42 | ||
rs4752571 | 123342567 | C | T | 0.398 | 1.39 | 4.02 × 10−41 | ||
rs2981583 | 123350523 | A | G | 0.399 | 1.384 | 2.71 × 10−39 | ||
10:123340431_GC_G | 123340431 | GC | G | 0.409 | 1.398 | 2.62 × 10−41 | ||
Chr11_70 | 11 | rs625668 | 69308369 | A | G | 0.122 | 1.227 | 5.02 × 10−15 |
rs657686 | 69332670 | G | A | 0.123 | 1.294 | 2.05 × 10−23 | ||
rs554219 | 69331642 | G | C | 0.123 | 1.292 | 2.95 × 10−23 | ||
Chr12_97 | 12 | rs11836367 | 96027467 | T | C | 0.35 | 0.88 | 3.66 × 10−8 |
Chr16_53 | 16 | rs4784227 | 52599188 | T | C | 0.244 | 1.31 | 1.57 × 10−32 |
Chr22_29 | 22 | rs62237617 | 28761148 | T | C | 0.002 | 2.90 | 7.41 × 10−16 |
Note: Statistics are calculated with corresponding recessive or dominant mode of transmission on the combined dataset.
Abbreviations: MAF, minor allele frequency; OR, odds ratio; SNP, single-nucleotide polymorphism.