Table 1.
Characteristics and uptake of HIV PrEP among 23 062 MSM attending sexual health clinics in Scotland between July 2015 and June 2019.
| Number of MSM attended at least oncea | Uptake of PrEPAmong MSM attending in the PrEP period | |||||
| Pre-PrEP(July 2015 to June 2017)N1 (col %) | PrEP period(July 2017 to June 2019)N2 (col %) | Pc | N3 (% of N2) | OR (95% CI) | aOR (95% CI) | |
| Total MSM | 14 319 | 16 723 | 3256 (19.5%) | |||
| Attendance history | ||||||
| Last attended within the last 2 years | 5404 (37.7%) | 6804 (40.7%) | <0.001 | 1846 (27.1%) | 1.00 | 1.00 |
| Last attended more than 2 years ago | 2670 (18.6%) | 3329 (19.9%) | 0.005 | 541 (16.3%) | 0.52 (0.47–0.58) | 0.53 (0.47–0.59) |
| Never attended in the history of NaSH | 6245 (43.6%) | 6590 (39.4%) | <0.001 | 869 (13.2%) | 0.41 (0.37–0.45) | 0.51 (0.47–0.57) |
| Age at first attendance (years) | ||||||
| Median (IQR) | 28 (22–37) | 28 (22–37) | 31 (25–41) | |||
| 15--24 | 4556 (31.8%) | 4798 (28.7%) | <0.001 | 766 (16.0%) | 1.00 | 1.00 |
| 25--39 | 6074 (42.4%) | 7571 (45.3%) | <0.001 | 1607 (21.2%) | 1.42 (1.29–1.56) | 1.32 (1.20–1.46) |
| 40--49 | 1923 (13.4%) | 2124 (12.7%) | 0.060 | 488 (23.0%) | 1.57 (1.38–1.78) | 1.54 (1.34–1.75) |
| 50+ | 1766 (12.3%) | 2230 (13.3%) | 0.009 | 395 (17.7%) | 1.13 (0.99–1.29) | 1.15 (1.00–1.32) |
| Ethnicity | ||||||
| White | 11 426 (79.8%) | 12 175 (72.8%) | <0.001 | 2577 (21.2%) | 1.00 | 1.00 |
| Non-White | 677 (4.7%) | 745 (4.5%) | 0.263 | 177 (23.8%) | 1.16 (0.98–1.38) | 1.20 (1.00–1.43) |
| Not known | 2216 (15.5%) | 3803 (22.7%) | <0.001 | 502 (13.2%) | 0.57 (0.51–0.63) | 0.67 (0.60–0.75) |
| NHS Board of Residence | ||||||
| Greater Glasgow and Clyde | 4576 (32.0%) | 5242 (31.3%) | 0.253 | 1191 (22.7%) | 1.00 | 1.00 |
| Lothian | 4063 (28.4%) | 4607 (27.5%) | 0.109 | 806 (17.5%) | 0.72 (0.65–0.80) | 0.68 (0.61–0.76) |
| Rest of Scotland | 5680 (39.7%) | 6874 (41.1%) | 0.010 | 1259 (18.3%) | 0.76 (0.70–0.83) | 0.77 (0.70–0.85) |
| Deprivation quintile of residence | ||||||
| 1 (Most deprived) | 2850 (19.9%) | 3140 (18.8%) | 0.013 | 661 (21.1%) | 1.00 | 1.00 |
| 2 | 2708 (18.9%) | 2987 (17.9%) | 0.018 | 615 (20.6%) | 0.97 (0.86–1.10) | 1.04 (0.91–1.18) |
| 3 | 2424 (16.9%) | 2748 (16.4%) | 0.248 | 586 (21.3%) | 1.02 (0.90–1.15) | 1.11 (0.97–1.26) |
| 4 | 2310 (16.1%) | 2601 (15.6%) | 0.168 | 480 (18.5%) | 0.85 (0.74–0.97) | 0.94 (0.82–1.08) |
| 5 | 2603 (18.2%) | 2888 (17.3%) | 0.038 | 500 (17.3%) | 0.79 (0.69–0.89) | 0.89 (0.78–1.02) |
| Not known | 1424 (9.9%) | 2359 (14.1%) | <0.001 | 414 (17.5%) | 0.80 (0.70–0.91) | 0.97 (0.85–1.12) |
| Ever injected drugs | ||||||
| No | 13 047 (91.1%) | 14 968 (89.5%) | <0.001 | 2946 (19.7%) | 1.00 | 1.00 |
| Yes | 277 (1.9%) | 293 (1.8%) | 0.250 | 103 (35.2%) | 2.21 (1.73–2.82) | 1.96 (1.52–2.53) |
| Not Known | 995 (6.9%) | 1462 (8.7%) | <0.001 | 207 (14.2%) | 0.67 (0.58–0.78) | 0.87 (0.74–1.02) |
| Testing and STI history in the last 12 monthsb | ||||||
| Prescribed HIV PEP and/or had a rectal STI | 1693 (11.8%) | 2087 (12.5%) | 0.081 | 746 (35.7%) | 5.23 (4.30–6.37) | 4.82 (3.94–5.89) |
| Had an STI (nonrectal) | 977 (6.8%) | 1081 (6.5%) | 0.213 | 246 (22.8%) | 2.77 (2.21–3.47) | 2.63 (2.09–3.31) |
| Had an STI or HIV test | 10 291 (71.9%) | 12 119 (72.5%) | 0.245 | 2126 (17.5%) | 2.00 (1.67–2.40) | 2.02 (1.68–2.43) |
| Not Tested and No STIs | 1358 (9.5%) | 1436 (8.6%) | 0.006 | 138 (9.6%) | 1.00 | 1.00 |
Unadjusted and adjusted odds ratios were generated from logistic regression models.
This excludes those that tested positive for HIV prior to their first attendance in the pre-PrEP period (n = 226) and PrEP period (n = 332).
Includes the day of first attendance in a period. STI only includes gonorrhoea and chlamydia. Patients have been assigned to only one category based on their highest risk factor.
P values come from a hypothesis test for equal proportions in the pre-PrEP and PrEP periods.
aOR, adjusted odds ratio; CI, confidence interval; IQR, interquartile range; NaSH, National Sexual Health Information System; OR, odds ratio; PEP, postexposure prophylaxis; PrEP, preexposure prophylaxis; STI, sexually transmitted infection.