Table 2. Adverse events (AE) following the yellow fever (YF) vaccination reported by 341 immunocompromised persons vaccinated with the vaccine from BioManguinhos or the one from Sanofi-Pasteur at the Reference Center for Immunobiologicals (CRIE) of Hospital das Clinicas of University of Sao Paulo Medical School, from September 2017 to December 2018.
| AE following vaccination | BioManguinhos (233) n (%) | Sanofi-Pasteur (108) n (%) | Total (341) n (%) |
|---|---|---|---|
| At least one AE | 74 (31.8) | 37 (34.3) | 111 (32.6) |
| Local AE | 26 (11.2) | 18 (16.7) | 44 (12.9) |
| Solicited local AE | |||
| Pain | 23 (9.9) | 18 (16.7) | 41 (12.0) |
| Edema | 0 | 5 (4.6) | 5 (1.5) |
| Erythema | 2 (0.8) | 1 (0.9) | 3 (0.9) |
| Unspecified local AE | 1 (0.4) | 0 | 1 (0.3) |
| Systemic AE | 54 (23.2) | 25 (23.2) | 79 (23.2) |
| Solicited systemic AE | |||
| Myalgia | 24 (10.3) | 10 (9.3) | 34 (10.0) |
| Fever | 17 (7.3) | 8 (7.4) | 25 (7.3) |
| Headache | 7 (3.0) | 9 (8.3) | 16 (4.7) |
| Unsolicited systemic AE | |||
| Asthenia | 8 (3.0) | 1 (0.9) | 9 (2.6) |
| Somnolence | 3 (1.3) | 0 | 3 (0.9) |
| Nausea/Vomiting | 3 (1.3) | 0 | 3 (0.9) |
| Malaise | 2 (0.9) | 1 (0.9) | 3 (0.9) |
| Diarrhea | 0 | 2 (1.9) | 2 (0.6) |
| Sore throat | 1 (0.4) | 1 (0.9) | 2 (0.6) |
| Facial edema** | 1 (0.4) | 0 | |
| Hoarseness | 1 (0.4) | 0 | 1 (0.3) |
| Cough | 0 | 1 (0.9) | 1 (0.3) |
| Jaundice | 1 (0.4) | 0 | 1 (0.3) |
| Papular lesions (on the back of hands and feet) | 1 (0.4) | 0 | 1 (0.3) |
| Arrhythmia | 1 (0.4) | 0 | 1 (0.3) |
| Joint swelling | 0 | 1 (0.9) | 1 (0.3) |
| “Neck heat” | 0 | 1 (0.9) | 1 (0.3) |
| Renal colic | 0 | 1 (0.9) | 1 (0.3) |
| Lower limbs paresthesia | 1 (0.4) | 0 | 1 (0.3) |
| Lymphadenomegaly | 1 (0.4) | 0 | 1 (0.3) |
| Abdominal pain | 1 (0.4) | 0 | 1 (0.3) |
| Pruritus | 1 (0.4) | 0 | 1 (0.3) |
| Chills | 1 (0.4) | 0 | 1 (0.3) |
| Hypertensive episode | 1 (0.4) | 0 | 1 (0.3) |
| Severe AE*** | 1 (0.4) | 3 (2.8) | 4 (1.2) |
| Hospitalization | 0 | 1 (0.9) | 1 (0.3) |
| Death | 1 (0.4) | 2 (1.9) | 3 (0.9) |
*12 vaccinees had both, local and systemic AE. Each vaccinee may have had ≥ 1 symptom; **A boy aged 57 months with history of egg allergy had facial edema that regressed with antiallergic drugs; ***None of the severe AEFI was considered related to the vaccination.