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. 2021 Jan 13;49(1):485–494. doi: 10.1042/BST20200981

Figure 2. VCP's effects on pressure overload induced cardiac hypertrophy.

Figure 2.

Pressure overload inhibits VCP in cardiomyocytes, reduces VCP's activation of mTORC2 signaling pathway and its inhibitory effect on mTORC1 signaling pathway, and ultimately leads to increased protein synthesis and cell apoptosis; However, overexpression of VCP can effectively restored the activation of mTORC2 signaling pathway and inhibited mTORC1 signaling pathway, and resisting myocardial hypertrophy caused by pressure overload.