FIG 5.

A cartoon showing the working model of the involvement of YejM in regulating LpxC levels. It is hypothesized that the periplasmic domain of YejM interacts with the FtsH/YciM complex to lower its proteolytic activity against LpxC. Also shown are the various domains of YciM and FtsH, where six suppressor alterations isolated in this study are located. FtsH-PD, periplasmic domain; FtsH-AAA, ATPase associated with diverse cellular activities; 4-helix, four-helix bundle; TPR, tetratricopeptide repeat; Cyto, cytoplasm; IM, inner membrane; Peri, periplasmic.