FIG 11.
Differential effects of bacteria in rectal microbiomes of male and female macaques on vaccine-induced immune responses, including those associated with protection. (A) Correlation of percentages of Bacteroidetes at week 38 with Env-specific rectal IgA levels at the same time point in vaccinated female and male macaques. Results of similar analyses of Bacteroidia and Bacteroidales are shown below without the actual plots. (B) Correlation of percentages of Proteobacteria at week 38 with phagocytic scores at the same time point in female and male macaques. Results of correlations with Epsilonproteobacteria and Campylobacterales are shown below. (C) Correlation of percentages of Cyanobacteria at week 38 with bone marrow EnvM766 IgA memory B cells in female and male macaques at the same time point. Results of correlations with Melainabacteria and Gastranaerophilales are shown below. (D) Correlation of Env-specific rectal IgA levels at week 38 with number of challenges in all vaccinated macaques. (E) Positive correlation of neutrophil phagocytic activity at week 38 in vaccinated males with number of challenges. (F) Lack of correlation of neutrophil phagocytic activity in vaccinated females with number of challenges. Results were obtained by Spearman rank correlation analyses.