FIG 12.

The rectal microbiome impacts immune responses; vaccine-induced alterations in the rectal microbiome impact viremia outcomes and induced immunity. (A) In vaccinated males, percentages of Bacilli do not correlate with peak viral loads prior to vaccination and following Ad5hr priming but do positively correlate following the booster immunization. (B) In vaccinated females, percentages of Fibrobacteres are negatively correlated with rectal Env-specific IgA levels prior to immunization but the correlation is lost following the Ad5hr prime and booster immunizations. (C) In vaccinated females, the percentages of Bacteroidetes prior to immunization and post-Ad5hr priming do not correlate with rectal Env-specific IgA levels but a positive correlation is seen following the booster immunization at week 38. Results were obtained by Spearman rank correlation analyses.