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. 2020 Nov 23;94(24):e01225-20. doi: 10.1128/JVI.01225-20

FIG 3.

FIG 3

Induction of binding and functional antibodies by the vaccine regimens. (A and B) Serum binding antibody titers (geometric mean) to SIV gp120 (M766 [A] and CG7V [B] strains) are shown over the course of immunization. Black arrows indicate mucosal priming immunizations at weeks 0 and 12; gray arrows indicate systemic booster immunizations at weeks 24 and 36. (C) A comparison of binding titers against both Env strains in the two vaccine arms is shown at week 38 (2 weeks after the second protein boost). (D) Serum neutralizing antibody titers against tier 1A SIVmac251.6 (mac251) and tier 1B SIVsmE660/BR-CG7V.IR1 (CG7V). (E and F) ADCC (percent killing) (E) and ADCP activity (F) are similarly shown at week 38 for both vaccine arms. (G and H) Rectal SIV Env-specific IgG (G) and IgA (H) binding antibodies are shown over the course of immunization for all vaccinated macaques. (I) Comparison of rectal Env-specific IgG and IgA at week 38 for the individual vaccine arms. *, P < 0.05; ***, P < 0.001; ****, P < 0.0001.