FIG 5.

The vaccine regimen strongly impacts the rectal microbiome. PCoA graphs were built using the Bray-Curtis dissimilarity matrix, a quantitative measure of community dissimilarity. (A) The difference in rectal microbiomes of male and female macaques prior to immunization. (B and C) Changes in rectal microbiomes of male (B) and female (C) macaques over the course of immunization. Combined PCoA plots include preimmunization, week 14, and week 38 time points. Statistical analysis was done using the PERMANOVA test for beta diversity.