FIG 6.

Analysis of the five most abundant bacterial phyla in the rectal microbiome of vaccinated macaques reveals the greatest changes in female macaques following Ad5hr priming. (A to D) Comparison of the relative abundances of the five most prevalent bacterial phyla for control and vaccinated macaques over the course of immunization and at 2 wpi. (E to I) The five most prevalent bacterial phyla found in the rectal microbiomes of the combined control plus vaccinated macaques, shown from most to least prevalent. In each panel, the relative abundance of each phylum is shown across the course of the vaccine regimen for males and females. Changes were most often detected between the preimmunization samples and post-Ad5hr immunization samples (week 14) and showed greatest statistical confidence for the female macaques, as indicated by the fold changes beneath the time points. *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001.