No differences between vaccinated males and females in SIV Gag-specific T cells in blood or rectal tissue or in serum binding antibodies, antibodies with functional activity, or antibodies in rectal secretions. (A to D) SIV Gag-specific memory CD8+ (A and C) and CD4+ (B and D) T cells in PBMCs (A and B) or in rectal tissue (C and D) at week 38 and 2 wpi. (E) SIVM766 and SIVCG7V gp120-specific binding antibody titers at week 38 in males and females. (F) SIVmac251.6 and SIVCG7V neutralizing antibody titers at week 38 in vaccinated males and females. (G) ADCC activity (percent killing) in males and females at week 38. (H) ADCP activity in males and females at week 38. (I and J) EnvM766-specific IgG (I) and IgA (J) in rectal secretions of males and females at week 38. *, P < 0.05; ***, P < 0.001; ****, P < 0.0001.