Skip to main content
. Author manuscript; available in PMC: 2021 Mar 3.
Published in final edited form as: Trends Pharmacol Sci. 2019 Jul 20;40(9):613–623. doi: 10.1016/j.tips.2019.07.001

Figure 1. Potential mechanism of immunotherapy-mediated tumor vascular normalization.

Figure 1.

Activation of effector T cells in the setting of ICB results in production and secretion of IFNγ, which, through interaction with IFNγ receptors (IFNGR) expressed on vascular cells, results in normalization of the tumor vasculature. EC = endothelial cell.