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. Author manuscript; available in PMC: 2021 Sep 1.
Published in final edited form as: Mol Cancer Res. 2020 Nov 2;19(3):361–374. doi: 10.1158/1541-7786.MCR-20-0687

Fig. 5: Active ERK2 homodimer interface.

Fig. 5:

A crystal of the phosphorylated ERK2 homodimer is shown to the left (PDB ID: 2ERK). A close-up of the dimer interface is shown at the right with key residues labelled. Select residues engaging in leucine zipper-like interactions are shown in pink. The two sets of residues forming a critical salt-bridge are shown in cyan. Figure adapted from Wilsbacher et al. 2006 (79).