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. Author manuscript; available in PMC: 2021 Sep 1.
Published in final edited form as: Clin Cancer Res. 2020 Oct 13;27(5):1227–1235. doi: 10.1158/1078-0432.CCR-20-2584

Figure 2. B7-H3 structure.

Figure 2.

B7-H3 is a type I transmembrane protein composed of an extracellular, a transmembrane and a short intracellular domain. Human B7-H3 exists in two isoforms as determined by its extracellular domain: 4IgB7-H3 which comprises two identical pairs of IgV-like and IgC-like domains (A), and 2IgB7-H3 which comprises a single pair of IgV-like and IgC-like domains (B). 4IgB7-H3 is the predominant isoform in humans. B7-H3 in mouse is expressed only as the 2IgB7-H3 isoform (C). IgV: immunoglobulin variable; IgC: immunoglobulin constant.