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. Author manuscript; available in PMC: 2022 Feb 1.
Published in final edited form as: Curr Opin Cell Biol. 2020 Nov 20;68:173–180. doi: 10.1016/j.ceb.2020.10.006

Figure 2. Ancestral LEM proteins tether chromatin and participate in nuclear structure.

Figure 2.

(A) Nuclear envelope repair coordinated by LEM2-CHMP7-ESCRTIII recruitment to BAF coated DNA. LEM2: orange, ESCRT: purple, BAF: pink. (B) Group I and II LEM proteins (LI/II) tether and silence (yellow gradient) peripheral heterochromatin via the recruitment of HDAC complexes (yellow). LEM domain: orange, MSC domain: dark grey.