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. Author manuscript; available in PMC: 2022 Mar 1.
Published in final edited form as: Breast Cancer. 2020 Nov 27;28(2):496–505. doi: 10.1007/s12282-020-01189-7

Figure 3. Predicted interaction network of EZH2 nuclear and cytoplasmic interacting proteins in metaplastic carcinomas.

Figure 3.

Enrichment analysis in STRING database (v11.0) of a recently reported quantitative proteomics landscape of metaplastic carcinomas [21] predicts the presence of EZH2 nuclear and cytoplasmic networks of EZH2 based on topological features from protein-protein interactions (p value < 1.0e-16). Selection of nuclear and cytoplasmic proteins were based on the literature [31, 32] and our recent study [20], respectively. Average clustering coefficients for canonical (0.84), non-canonical (0.63) and both clusters (0.66) represent a correlation representative of distinct EZH2 mechanisms.