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. Author manuscript; available in PMC: 2022 Apr 1.
Published in final edited form as: Prog Neurobiol. 2020 Nov 26;199:101963. doi: 10.1016/j.pneurobio.2020.101963

Fig. 3.

Fig. 3.

Bulk RNAseq analysis of transcriptome changes of wild-type and Nhe1 Astro-KO astrocytes. (A) Schematics of bulk RNAseq analysisof astrocyte isolated from wild-type and Nhe1 Astro-KOischemic brains at 24 h Rp. n=3. (B) Venn diagram depicting differential gene expression in astrocytes from wild-type and Nhe1 Astro-KObrains (log2 fold change 1.2 and FDR p value < 0.05). (C) Heat map and unsupervised hierarchial clustering illustrates up-and down-regulated genes. (D) Volcano plots illustrates the gene expression pattern detected with log2 fold change 1.2 and an adjusted FDR p-value <0.05. (E) Significantly altered canonical pathways by Ingenuity pathway analysis (IPA).