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. Author manuscript; available in PMC: 2022 Apr 1.
Published in final edited form as: Prog Neurobiol. 2020 Nov 26;199:101963. doi: 10.1016/j.pneurobio.2020.101963

Fig. 6.

Fig. 6.

Pharmacological inhibition of Wnt/β-catenin signaling by β-catenin specific inhibitor XAV-939 abolished the BBB protection in Nhe1Astro-KO brains after ischemic stroke. (A) Representative confocal images showing albumin immunofluorescence staining in ischemic peri-lesion areas of wild-type and Nhe1 Astro-KO brains treated with vehicle and XAV-939 at 24 h Rp. (B) Summary of albumin infiltration. Albumin immunoreactivity was quantified by measuring the fluorescence intensity of images in panel A and B. Data are mean ± SEM, n = 5, *p < 0.05 (three-way ANOVA followed by Newman-Keuls multiple comparisons test). (C) Representative images of DAB-positive red blood cells showing the presence of intracerebral hemorrhages in the IL cortex of XAV-939 treated brains at 24 h Rp. (D) Quantification of the hemorrhagic percent area. Data are mean ± SEM, n = 5, *p < 0.05 (three-way ANOVA followed by Newman-Keuls multiple compari-sons test).