Skip to main content
. Author manuscript; available in PMC: 2021 Sep 1.
Published in final edited form as: Mol Cancer Res. 2020 Nov 10;19(3):451–464. doi: 10.1158/1541-7786.MCR-20-0453

Figure 5. TET2 regulated enhancers are hypermethylated, more rapidly remethylated, and impact erythroid gene expression.

Figure 5.

A) Genome browser track highlighting 5mC and 5hmC differences centered in the SLC4A1 enhancer/promoter (Enh./Prom.) region. Enhancer annotation was derived from GeneHancer Regulatory Interactions (double elite) table on UCSC genome browser. DHMR = Differentially Hydroxymethylated Region (as determined by differential peak enrichment analysis of HMCP-Seq data). B) Mean % methylation during 5-Aza treatment for CpGs within highlighted box in (A). C) Normalized expression of SLC4A1 during 5-Aza treatment; “*” = FDR < 0.1; “**” = FDR < 0.01. D) As shown for SLC4A1, global methylation kinetics for CpGs located within DHMR peaks show more rapid remethylation kinetics after 5-Aza in TET2KO cells.