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Inhibition potency of warfarin and VK-M-COT for VKOR mutations
| VKOR | IC50 ± standard deviation (nM) | |
|---|---|---|
| VK-M-COT | Warfarin | |
| Wild type | 616 ± 74 | 5.9 ± 0.6 |
| A26P | 487 ± 75 | 360 ± 33 |
| F55A | 249 ± 66 | 2460 ± 235 |
| W59R | 615 ± 101 | 498 ± 37 |
| L128R | 575 ± 132 | 416 ± 49 |
| Y139F | 658 ± 54 | 633 ± 67 |
