Table 2:
Multivariable analysis and sensitivity analysis for the association between early treatment discontinuation and breast cancer recurrence among 4,503 premenopausal women diagnosed with breast cancer in Denmark (2002–2011) in the ProBe CaRe cohort.
| Multivariable Analysis | Sensitivity Analysisa | |
|---|---|---|
| Model | HR (95%CI) | HR (95%CI) |
| Unadjusted | 1.59 (1.27, 2.00) | 1.44 (1.12, 1.83) |
| Adjustedb | 1.63 (1.30, 2.04) | 1.49 (1.15, 1.92) |
| G Computationc | 1.67 (1.25, 2.14) | 1.41 (1.15, 1.67) |
a
Allows 1.5 years from last prescription and end of follow-up
b
Baseline confounders include: age, stage, surgery type, radiation therapy, chemotherapy, statin use, comorbidity index, income, marital status, and education
c
Time-varying confounders include: switch from tamoxifen to aromatase inhibitors, new comorbidity diagnosis, new medication use
Abbreviations: HR=hazard ratio; CI=confidence interval