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. Author manuscript; available in PMC: 2021 Sep 1.
Published in final edited form as: Cancer Immunol Res. 2021 Jan 13;9(3):348–361. doi: 10.1158/2326-6066.CIR-20-0428

Fig. 2. Notch2-dependent DCs are essential for limiting colitis-associated CRC development.

Fig. 2

WT mice were transplanted with CD11c-Cre/Notch2F/+ (D-N2+/−) (n=10) or CD11c-Cre/Notch2F/F (D-N2−/−) marrow (n=10), and Fx−/− mice received WT (CD11c-Cre/Notch2+/+ or Notch2F/F) (n=12), CD11c-Cre/Notch2F/+ (D-N2+/−) (n=14) or CD11c-Cre/Notch2F/F (D-N2−/−) bone marrow cells (n=15). Data were pooled from 4 experiments. Colon inflammation (A) and dysplastic scores (B) were recorded 2 months after transplantation. (C-D) Representative H&E staining of colonic tissues from Fx−/− mice transplanted with D-N2+/− or D-N2−/− cells show worse inflammation in D than C (20X magnification). Black bars (A-B) indicate means. Student t-test was performed; p-values were shown.