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. Author manuscript; available in PMC: 2021 Sep 1.
Published in final edited form as: Cancer Immunol Res. 2021 Jan 13;9(3):348–361. doi: 10.1158/2326-6066.CIR-20-0428

Fig 6. Adoptive transfer of Notch-primed DCs limited inflammation associated transformation.

Fig 6.

(A) Schematic of in vitro priming of bone marrow-derived DCs with OP9-DLL1 in the presence of Flt3L and adoptive transfer. (B) Colon inflammation and dysplastic scores were recorded 5 days after the last dose of DC transfer (n=9) or PBS injection (control; n=6). Data were pooled from 3 experiments. (C) Representative H&E staining of colonic tissues from Fx−/− mice received PBS (control) or primed DCs. (D) Inflammatory cytokine mRNA expression in colon tissue from Fx−/− mice receiving PBS or DC injection was measured by qRT-PCR and normalized to the expression in Fx−/− mice receiving PBS. Results shown in B and D are mean ± SD. Student t-test was performed; *p<0.05, **p<0.01