Table 1.
Inflammation score, dysplasia score, and CRC frequency in transplanted Fx−/− mice
| Donor | Mean Inflammation Score | Mean Dysplastic Score | Number of mice | CRC Frequency |
|---|---|---|---|---|
| WT | 7.04 | 17.9 | 12 | 2/12 |
| Fx | 11.06 | 42.2 | 9 | • * |
| Mx-Cre/Rbpjk+/+ or RbpjkF/F | 6.1 | 19.4 | 8 | 3/8 |
| Mx-Cre/RbpjkF/+ | 8 | 28 | 10 | 4/10 |
| Mx-Cre/RbpjkF/F | 12.8 | 50 | 9 | 7/9 |
| Vav-Cre/N1F/+ | 9.4 | 16 | 5 | 0/5 |
| Vav-Cre/N1F/F | 9 | 13 | 5 | 0/5 |
| Vav-Cre/N2F/+ | 7.6 | 30 | 5 | 1/5 |
| Vav-Cre/N2F/F | 12.3 | 46.7 | 6 | 3/6 |
| CD4-Cre/RbpjkF/+ | 5.3 | 21.2 | 8 | 2/8 |
| CD4-Cre/RbpjkF/F | 4.8 | 14 | 10 | 0/10 |
| Lys-Cre/RbpjkF/+ | 7.1 | 15.7 | 7 | 1/7 |
| Lys-Cre/RbpjkF/F | 8.5 | 25 | 6 | 0/6 |
| CD11c-Cre/N2+/+ or N2F/F | 7 | 17.9 | 12 | 3/12 |
| CD11c-Cre/N2F/+ | 7.7 | 28 | 15 | 6/15 |
| CD11c-Cre/N2F/F | 9.6 | 38.4 | 16 | 7/16 |
*
Mice all died less than 2 months after bone marrow transfer.